Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages

The aim of this study was to evaluate for the first time anti-inflammatory effects chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment two markedly decreased apoptosis stimulated wound healing LPS, where they also reduced intracellular levels ROS nitrite. Additionally, treatment LPS glutathione suppressed antioxidant enzyme activities, which were significantly (p < 0.05) increased presence honeys, through modulation Nrf2 expression; LPS-stressed macrophages, Chestnut or protected against inflammation by regulating main inflammatory biomarkers, including TNF-?, IL-10 iNOS, decrease NF-?B expression. Finally, improved mitochondrial respiration related parameters.